transglutaminase (Tgase)

By Targets:	Apoptosis (3) Caspase (3) Glutaminase (4)
By Research Areas:	Cancer (3) Neurological Disease (1)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-124476

Cystamine	Caspase Glutaminase Apoptosis	Cancer
Cystamine is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active **transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC₅₀** value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) .

HY-W020050

Cystamine (dihydrochloride）	Caspase Glutaminase Apoptosis	Neurological Disease Cancer
Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active **transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC₅₀** value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD) .

HY-12337

GK921

3 Publications Verification

Glutaminase Cancer

GK921 is a transglutaminase 2 (TGase) inhibitor with an IC₅₀ of 7.71 μM for human recombinant TGase 2.

GK921 3 Publications Verification	Glutaminase	Cancer
GK921 is a transglutaminase 2 (TGase) inhibitor with an IC₅₀ of 7.71 μM for human recombinant TGase 2.

HY-W020050S

Cystamine-d8 (dihydrochloride）	Apoptosis Caspase Glutaminase
Cystamine-d₈ (dihydrochloride） is the deuterium labeled Cystamine (dihydrochloride）[1]. Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD)[2][3][4].

Species:	Human (3) Mouse (2)
Tag:	His (5)
Source:	HEK293 (1) Sf9 insect cells (3) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source

HY-P78361

	TGM2/Transglutaminase 2 Protein, Mouse (His) Heart G alpha(h); TGM2; tTG; tTgase; transglutaminase C; TG(C); TGC; TGase C; transglutaminase H; TGase II; transglutaminase-2; TG2; G-ALPHA-h; GNAH; HEL-S-45; C polypeptide; TGase-2; TGase-H; TGCGNAH	Mouse	E. coli
	TGM2/Transglutaminase 2 protein, a calcium-dependent acyltransferase, catalyzes the formation of covalent bonds between peptide-bound glutamine and various primary amines, leading to the cross-linking or amination of proteins. Involved in diverse biological processes such as bone development, angiogenesis, wound healing, cellular differentiation, chromatin modification, and apoptosis, TGM2 acts as a protein-glutamine gamma-glutamyltransferase. It mediates the cross-linking of proteins, including ACO2, HSPB6, FN1, HMGB1, RAP1GDS1, SLC25A4/ANT1, SPP1, and WDR54. The protein cross-linking activity is inhibited under physiological conditions by GTP, and this inhibition is relieved by Ca(2+) in response to various stresses. In addition to its role in apoptosis by promoting cytoskeletal protein cross-linking and mediating the formation of extracellular matrix scaffolds, TGM2 can use monoamine substrates to catalyze diverse protein post-translational modifications. It plays a crucial role in chromatin organization by mediating serotonylation and dopaminylation of histone H3, contributing to neurotransmission-independent functions in ventral tegmental area (VTA) neurons. Furthermore, TGM2 acts as a signal transducer in alpha-1 adrenergic receptor-mediated stimulation of phospholipase C-delta (PLCD) activity, highlighting its involvement in signaling pathways beyond its acyltransferase activity. TGM2/Transglutaminase 2 Protein, Mouse (His) is the recombinant mouse-derived TGM2/Transglutaminase 2 protein, expressed by E. coli , with N-His labeled tag. The total length of TGM2/Transglutaminase 2 Protein, Mouse (His) is 685 a.a., with molecular weight of ~78.2 kDa.

HY-P77257

	Transglutaminase 3/TGM3 Protein, Human (sf9, His) Protein-glutamine gamma-glutamyltransferase E; transglutaminase E; TGase-3	Human	Sf9 insect cells
	Transglutaminase 3 (TGM3) serves as a catalyst in the calcium-dependent formation of isopeptide cross-links between glutamine and lysine residues in diverse proteins, alongside mediating the conjugation of polyamines to proteins. This enzymatic activity plays a crucial role in the intricate process of cornified envelope (CE) formation, a specialized structure comprising covalent cross-links of proteins beneath the plasma membrane in fully differentiated keratinocytes. TGM3 is actively involved in cross-linking small proline-rich proteins (SPRR1 and SPRR2) and loricrin (LOR) to create small interchain oligomers. These oligomers are subsequently cross-linked by TGM1 onto the developing CE scaffold, contributing to the structural integrity of this vital component. Notably, TGM3's involvement extends to hair follicles, where it participates in cross-linking structural proteins to fortify the inner root sheath. Transglutaminase 3/TGM3 Protein, Human (sf9, His) is the recombinant human-derived Transglutaminase 3/TGM3 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of Transglutaminase 3/TGM3 Protein, Human (sf9, His) is 692 a.a., with molecular weight of ~70 kDa.

HY-P71132

	TGM2/Transglutaminase 2 Protein, Mouse (HEK293, His) Protein-glutamine gamma-glutamyltransferase 2; Tgm2; Tissue transglutaminase; transglutaminase C; TGase-2	Mouse	HEK293
	The TGM2/transglutaminase 2 protein is a calcium-dependent acyltransferase involved in bone development, angiogenesis, wound healing, and apoptosis. TGM2 is also involved in neurotransmission-independent actions and serves as a signal transducer in α-1 adrenergic receptor-mediated pathways. TGM2/Transglutaminase 2 Protein, Mouse (HEK293, His) is the recombinant mouse-derived TGM2/Transglutaminase 2 protein, expressed by HEK293 , with C-6*His labeled tag. The total length of TGM2/Transglutaminase 2 Protein, Mouse (HEK293, His) is 685 a.a., with molecular weight of 70-90 kDa.

HY-P76114

	TGM2/Transglutaminase 2 Protein, Human (sf9, His) Protein-glutamine gamma-glutamyltransferase 2; transglutaminase C; TGase-2	Human	Sf9 insect cells
	In summary, TGM2 is a multifunctional enzyme that plays crucial roles in various cellular processes. It acts as a protein-glutamine gamma-glutamyl transferase, mediating the cross-linking of proteins involved in cellular functions. TGM2/Transglutaminase 2 Protein, Human (sf9, His) is the recombinant human-derived TGM2/Transglutaminase 2 protein, expressed by Sf9 insect cells , with N-His labeled tag. The total length of TGM2/Transglutaminase 2 Protein, Human (sf9, His) is 687 a.a., with molecular weight of ~80 kDa.

HY-P76114Y

TGM2/Transglutaminase 2 Protein, Human (sf9, His, solution)

Protein-glutamine gamma-glutamyltransferase 2; transglutaminase C; TGase-2
Human Sf9 insect cells


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Cat. No.	Product Name	Chemical Structure

HY-W020050S

Cystamine-d8 (dihydrochloride）
Cystamine-d₈ (dihydrochloride） is the deuterium labeled Cystamine (dihydrochloride）[1]. Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD)[2][3][4].

Cystamine-d8 (dihydrochloride）

Cystamine-d₈ (dihydrochloride） is the deuterium labeled Cystamine (dihydrochloride）[1]. Cystamine (dihydrochloride) is the disulfide form of the free thiol, cysteamine. Cystamine is an orally active transglutaminase (Tgase) inhibitor. Cystamine also has inhibition activity for caspase-3 with an IC50 value of 23.6 μM. Cystamine can be used for the research of severals diseases including Huntington's disease (HD)[2][3][4].

Cat. No.	Product Name	Application	Reactivity

HY-P82510

Transglutaminase 2 Antibody (YA2255) TGM2; Protein-glutamine gamma-glutamyltransferase 2; Tissue transglutaminase; transglutaminase C; TG(C); TGC; TGase C; transglutaminase H; TGase H; transglutaminase-2; TGase-2	WB, IHC-P, IP	Human, Mouse, Rat

HY-P81886

Factor XIIIa Antibody (YA1631)

Coagulation factor XIIIa; F13A; F13a1; Fibrin stabilizing factor; A subunit; Fibrinoligase; TGase; transglutaminase A chain
WB, IHC-P Human

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